Thrombin generation, a function test of the haemostaticthrombotic system

Thrombin generation, a function test of the haemostatic-thrombotic system.

By the use of a fluorogenic thrombin substrate and continuous calibration of each individual sample, it is now possible to obtain a thrombin generation (TG) curve (or thrombogram) in plasma, with or without platelets, in an easy routine procedure at high throughput and with an acceptable experimental error (<5%). Evidence is growing that the parameters of the thrombogram, and notably the area u...

a study on construction of iranian life tables: the case study of modified brass logit system

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Global Test of Haemostasis: Thrombin Generation Assay

A thrombin generation test; the application in haemophilia and thrombocytopenia.

Much recent research on blood clotting has dealt with prothrombin and factors which influence its activation. In the development of such investigations experimental procedures have become increasingly complex and artificial. They usually involve the use of anticoagulants, often multistage fractionation by precipitation, adsorption or filtration, and, almost invariably, the addition of tissue ex...

Increased thrombin generation after acute versus chronic coronary disease as assessed by the thrombin generation test.

Atherosclerosis is the most common pathophysiologic substrate of coronary artery disease (CAD). Whereas plaque progression and arterial remodeling are critical components in chronic CAD, intracoronary thrombosis over plaque disruption is causally related to acute CAD. It was the objective of this study to investigate the differences between prior acute CAD and chronic CAD by a simple global coa...